On June 5, 2008, the “Act on Special Cases Concerning the Simplification of Authorization and Permission Procedures for Industrial Complexes” (Act No. 9106) was enacted. When it was implemented in August 2008, many industrial complex development projects were established, and the number of industrial complexes growth rates of 3 6% during 2003 2007 rose to around 15% in 2008. With the increase in industrial complexes, the environmental impacts of individual projects were examined, but comprehensive regional reviews of environmental impacts were not undertaken. In this study, we determined changes in air quality by applying the industrial complex development plan that completed the consultation at the end of 2010 to assess the comprehensive regional environmental impacts and presented the adequacy review plan for future industrial development plans based on the study’s results. When considering these industrial complex development plans, emissions in North Jeolla and South Chungcheong Provinces and Daegu City have increased significantly. Air quality analyses showed that the 24 h mean SO2 concentration in Daegu increased by more than 50% in summer compared to air quality concentrations in summer. The 24 h mean PM10 and NO2 concentrations increased by approximately 12 and 30%, respectively, in North Jeolla Province in summer. Areas exceeding the air quality standard for 1 h mean O3 concentration increased by more than 3,500 km2. Based on the above analysis, changes in air quality should be anticipated through a comprehensive evaluation of long-term development plans. Furthermore, control of air quality in accordance with the development of future industrial complexes is possible.