In this study, 40 residents of the Gwangyang and Yeosu areas were assessed for their level of exposure to heavy metals (As, Cd, Ni) from April 2017 to June 2018. The aim was to understand the differences in levels of indoor exposure to heavy metals (As, Cd, Ni), and a health risk assessment was conducted to determine whether there was any fatal cause from carcinogenic elements. The mean concentrations of PM10 particles indoors were As 0.24 μg/m3, Cd 0.07 μg/m3, and Ni 0.89 μg/m3. The health risk assessment for the arsenic, cadmium, and nickel in indoor air confirmed that the mean values exceeded the cancer risk tolerances specified by the U.S. EPA, for As (males 3.07 × 10−4, females 3.35 × 10−4), Cd (males 3.83 × 10−5, females 4.18 × 10−5), and Ni (males 6.36 × 10−5, females 6.95 × 10−5).