Mahalanobis Taguchi System (MTS) is developed by Genishi Taguchi as a part of his quality engineering methodology. The basic idea of Taguchi's quality engineering is looking for the way of effectiveness of analyzing multivariate system. In the MTS, with the standardized variables of healthy normal data, Mahalanobis Distance(MD) calculated and that can be discriminate between normal and abnormal objects. If this discrimination process is successful, next step is optimization which is try to reduce number of attributes by neglecting less effective attributes to MD. Orthogonal Array (OA) and Signal to Noise ratio (S/N) are used to evaluate the amount contribution of each attribute to the MD. Wisconsin Breast Cancer study, from machining learning repository at University of California at Irvine, used for examining the discriminant ability of MTS.