Cerebrovascular and cardiovascular diseases (CVDs) are a major cause of deaths among workers as well as in general population in Korea. Occupational stress like long working hours or overwork can cause sudden unexpected death in a worker who had been suffering from an aggravated preexisting condition such as hypertensive or arteriosclerotic diseases, The Korean government has compensated the cases of cerebrovascular disease and cardiovascular disease due to overwork, but neither a resonable definition of overwork nor detailed evaluation guideline has been officially provided to verify overwork, so that the prevention of, as well as compensation for workers' occupational stress-related cardiovascular attacks, cannot be carried out efficiently. A thorough understanding of the etiopathology of WR-CVDs can be very helpful in developing a prevention strategy.