Spinal pain is a symptom caused by changes of the vertebral column or its adnexa. Sometimes spinal pain cannot be treated, especially in case of multiple pain lesions, because of its difficulty in evaluating original causes which contributes to the symptoms. Thus, the precise localization of the lesion causing symptoms is very important for targeted treatment. However, the diagnosis based on limited screening test including physical evaluation and radiological finding may lead to misdiagnosis of the actual lesion causing symptoms, failure of treatment, and unnecessary surgery. From this point of view, nonsurgical interventional for spinal pain can be helpful to diagnose the precise cause of spinal pain. We report several cases that nonsurgical interventional therapy which diagnosed the precise lesion that cause the spinal pain and treated successfully with nonsurgical interventional therapy for diagnostic purposes with therapeutic purpose.