This study explored the risk assessment framework of multi-story piping system installed in critical facilities, in particular, seismically base-isolated building systems. In order to understand the seismic performance of multi-story piping system, OpenSees platform was used in this study. Also, Triple Friction Pendulum Bearing as a seismic base isolator was conducted in OpenSees. The focus of this study was on the development of seismic fragility or vulnerability of seismically isolated piping system.