A smart connective control system was invented recently for coupling control of adjacent buildings. Previous studies on this topic focused on development of control algorithm for the smart connective control system and design method of control device. Usually, a smart control devices are applied to building structures after structural design. However, because structural characteristics of building structure with control devices changes, a iterative design is required for optimal design. To defeat this problem, an integrated optimal design method for a smart connective control system and connected buildings was proposed. For this purpose, an artificial seismic load was generated for control performance evaluation of the smart coupling control system. 20-story and 12-story adjacent buildings were used as example structures and an MR (magnetorheological) damper was used as a smart control device to connect adjacent two buildings. NSGA-II was used for multi-objective integrated optimization of structure-smart control device. Numerical simulation results show the integrated optimal design method proposed in this study can provide various optimal designs for smart connective control system and connected buildings presenting good control performance.