This study investigated the prokinetic effect of metoclopramide and mirtazapine on gastric transit time (GTT), small bowel transit time (SBTT) and gastrointestinal transit time (GITT) during capsule endoscopy in four healthy beagle dogs. Four beagle dogs participated in the experiment as four groups at intervals of more than three days as the following: Control group 1 (capsule alone), Control group 2 (capsule alone), Metoclopramide administered group (metoclopramide + capsule) and Mirtazapine administered group (mirtazapine + capsule). The results of this study demonstrated there was no significant difference in GTT ([min] control group 1: 105 ± 90, control group 2: 172.5 ± 102 vs metoclopramide administered group: 247.5 ± 93, p = 0.07, 0.10) and SBTT ([min] control group 1: 120 ± 88, control group 2: 75 ± 39 vs metoclopramide administered group: 37.5 ± 15, p = 0.20, 0.18) for capsule only administered groups (control group 1 & 2) compared to metoclopramide administered group. In addition, there was no significant difference in GTT ([min] control group 1: 105 ± 90, control group 2: 172.5 ± 102 vs mirtazapine administered group: 127.5 ± 45, p = 0.56, 0.36) and SBTT ([min] control group 1: 120 ± 88, control group 2: 75 ± 39 vs mirtazapine administered group: 157.5 ± 38, p = 0.29, 0.07) between capsule only administered groups (control group 1 & 2) and mirtazapine administered group. In this study, the fact that metoclopramide might be ineffective and administration of mirtazapine might be inadequate in dogs were confirmed.

Introduction
 Materials and Methods
  Animals
  Capsule endoscope procedure
  Image analysis
  Statistical analysis
 Results
  Baseline characteristics of the dogs
  The rate of complete capsule endoscopy proceduresand gastrointestinal trasit time
  Effect analysis of metoclopramide regarding thegastrointestinal transit time
  Effect analysis of mirtazapine regarding the gastrointestinaltransit time
 Discussion
 References

• Gyu-Dong Kim(Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
• Joong-Hyun Song(Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
• Do-Hyeon Yu(Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
• Hee-Chun Lee(Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
• Su-Jin An(Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
• Dong-In Jung(Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) Corresponding author
• Young Joo Kim(College of Veterinary Medicine, Western University of Health Sciences)