We aimed to evaluate antithrombotic efficacy of Protaetia brevitarsis extract during 21 days. Rats (SPF rat, weight 240~260 g) were divided into 16 groups (5 rats per group), they were: control group and Protaetia brevitarsis extract groups with dose of 0.1, 0.5, 1, 2.5, 5, 10, 25, 50, 75, 100, 200, 250, 500, 750, 1,000 mg/kg kg of body weight. Thromboplastin time (PT) and activated partial thromboplastin time (aPPT) as antithrombotic efficacy were tested in this animal experiment (at 7, 14 and 21 days). Overall, the admistration dose of Protaetia brevitarsis extract over 50 mg/kg at 7, 14 and 21 days for PT and over 25 mg/kg at 7, 14 and 21 days for aPPT tented to be longer than that of other groups. In addition, the optimal admistration doses of Protaetia brevitarsis extract to improves antithrombotic efficacy were 75, 100, 200 and 250 mg/kg at 7, 14 and 21 days for PT (p<0.05) and 50 and 100 mg/kg at 7 days, 75 mg/kg at 14 days, or 50, 100, 200 and 250 mg/kg at 21 days for aPPT (p<0.05). It can be concluded that Protaetia brevitarsis extract at optimal levels have antithrombotic efficacy.

Abstract
 1. 서 론
 2. 연구 방법
 3. 결과 및 고찰
 4. 결 론
 REFERENCES

• 최인학(중부대학교 바이오융합학부) | In-Hag Choi (Department of Companion Animal & Animal Resource, Joongbu Univeristy)
• 유리(중부대학교 바이오융합학부) | Ri Yu (Department of Companion Animal & Animal Resource, Joongbu Univeristy)
• 임연지(중부대학교 바이오융합학부) | Yeon-Ji Lim (Department of Companion Animal & Animal Resource, Joongbu Univeristy)
• 최규성(중부대학교 바이오융합학부) | Gyu-Sung Choi (Department of Companion Animal & Animal Resource, Joongbu Univeristy)
• 최성업(동남보건대학교 식품제약과) | Sung-Up Choi (Food and Pharmaceutical Science, Dongnam Health University)
• 황종익(고려대학교 의과대학) | Jong-Ik Hwang (College of Medicines, Korea University)
• 손진성(HMO Health Dream Agricultural Association Corporation) | Jin-Sung Son
• 정태호(중부대학교 바이오융합학부) | Tae-Ho Chung (Department of Companion Animal & Animal Resource, Joongbu Univeristy) Corresponding author