When air with high humidity is stagnant in a huge hot-rolling building, condensation occasionally occurs on the surface of hot-rolling steel coils, degrading quality of the products. To resolve this problem, we tried to utilize the natural ventilation effectively by modifying the location and size of opening vents based on quantitative visualization of ventilation flow inside the factory building. The 1/850 scale-down building model was embedded inside an atmospheric boundary layer simulated in a wind tunnel. The effects of wind direction and location of opening vents on the ventilation flow inside the factory building were investigated experimentally. Instantaneous velocity fields inside the building model were measured using a 2-frame PIV system. Among four dominant wind directions for the building tested, the condensation phenomena occurred monthly for the case of south wind. The addition of a vent on the southern wall of the factory building improved the natural ventilation effectively.