Central precocious puberty (CPP) is less common in boys than girls; very little data is reported on effect of gonadotropin-releasing hormone analog (GnRHa) treatment in boys with CPP. The aim of the study was to evaluate growth changes in boys with CPP and early puberty (EP) treated with GnRHa therapy for 1 year. In 60 (39 CPP and 21 EP) boys with confirmed diagnosis of CPP and EP, auxological [height, height standard deviation score (Ht SDS), bone age (BA), Predicted adult height (PAH)] and endocrinological parameters were obtained at baseline, at 6 months, and at 1 year after GnRHa treatment in boys with CPP and EP. During the treatment a decline in Ht SDS and growth velocity, luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone levels were observed (p＜0.01); and a deceleration in the maturation of bones after 1 year GnRHa treatment was observed (p＜0.01). PAH SDS was increased during treatment with GnRHa (p＜0.01). There was significant difference in PAH SDS between organic CPP and non-organic CPP (p＜0.05). The present data indicate that GnRHa therapy significantly improves growth prognosis in boys with CPP and EP.

서론
대상 및 방법
    연구대상 및 방법
    통계
결과
    진성 성조숙증(CPP)과 조기 사춘기(EP) 두 군의 진단시 임상인자의 특성
    GnRHa 치료 6개월 및 1년 후 진성 성조숙증(CPP) 및조기 사춘기(Early puberty)군의 임상인자의 특성
    전체 환아에서 특발성(54명)군과 기질성(6명)군의GnRHa 치료시기에 따른 임상인자의 비교
고찰
참고문헌

• 조아영(조선대학교병원 소아청소년과) | Ah Young Cho (Department of Pediatrics, Chosun University Hospital)
• 이재희(조선대학교병원 소아청소년과) | Jae Hee Lee (Department of Pediatrics, Chosun University Hospital)
• 김은영(조선대학교병원 소아청소년과) | Eun Young Kim (Department of Pediatrics, Chosun University Hospital) Corresponding author