Lightly reinforced concrete (RC) moment frames may suffer significant damage during large earthquake events. Most buildings with RC moment frames were designed without considering seismic loads. The load-displacement response of gravity load designed frames could be altered by masonry infill walls. The objective of this study is to investigate the load-displacement response of gravity load designed frames with masonry infill walls. For this purpose, three-story gravity load designed frames with masonry infill walls were considered. The masonry infilled RC frames demonstrated larger lateral strength and stiffness than bare RC frames, whereas their drift capacity was less than that of bare frames. A specimen with a partial-height infill wall showed the least drift capacity and energy dissipation capacity. This specimen failed in shear, whereas other specimens experienced a relatively ductile failure mode (flexure-shear failure).