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The Beneficial Effect of Avocado on Skin Inflammation in a Mouse Model of AD-like Skin Lesions KCI 등재
pp.705-713
Avocado, superfood, contains a variety of essential nutrients and phytochemicals. The purpose of this study was to explore whether avocado could modulate skin inflammation in vivo. We elucidated the pharmacological effects of avocado on compound 48/80- or histamine-induced scratching behaviors and 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)-like skin lesions in mice. Additionally, we investigated the anti-inflammatory activity of avocado and its underlying mechanism including its effect on the expression levels of inflammatory-related genes and nuclear factor -κB (NF-κB) in DNCB-induced AD-like skin lesions. The findings of this study demonstrate that avocado attenuated AD clinical symptoms including itching, eczematous, erythema and dryness and histamine levels in mice. Moreover, avocado suppressed both inflammatory cytokines expression as well as NF-κB and caspase-1 activation in AD-like skin lesions in mice. Taken together, these results demonstrate that avocado may be a potential candidate for treating skin inflammatory diseases like AD.
Materials and Methods
Reagents
Animals
Preparation of avocado extracts
Scratching behavioral experiment
Induction of AD-Like Skin Lesions and avocado treatment
Evaluation of skin dermatitis severity
Histamine assay
Cytokine Assay
Western blot analysis
Caspase-1 activity
Statistical analysis
Results
Avocado suppress scratching behaviors in mice
Avocado suppress AD symptoms in DNCB-induced AD-like skin lesions
Avocado suppress IgE and histamine serum levels in DNCB-induced AD mice
Avocado suppress the inflammatory cytokines expression in AD-like skin lesions
Avocado suppress the NF-κB activation in AD-like skin lesion
Avocado suppress caspase-1 activation in AD-like skin lesion
Discussion
References
