We have observed the 10-9 transitions of HC3N and its 13C substitutes (H13CCCN,HC13CCN, and HCC13CN), and the vibration ally excited 12-11 (vr=1) HC3N transition toward the Sgr B2 molecular cloud. The observed HC3N emission shows an elongated shape around the Principal Cloud (~4.5 pc in R.A. × 7.4 pc in Decl.). The optically thin H13CCCN line peaks around the (N) core and we derive the total column density N(H13CCCN) = 4 ×10 13 cm-2 at this position. Toward the 2' N cloud which shows the peculiar chemistry, the HC3N lines show enhancements compared to the extended envelope. The shocks of the 2' N may have resulted in the enhancement of HC3N. The hot component of HC3N is strongly concentrated around the (N) core and its HPW is ~0.9 pc in diameter. We derive the lower limit of the abundance ratio N(HC3N)/N(H13CCCN) to be larger than 40 in most regions except the (M) and (N) cores. The fractionation processes of 13C at this region may not be as effective as previously reported.