This paper reports a survey done that examined the relationship between the use of Facebook, WhatsApp, Twitter and Youtube on students’ academic performance in Osun State secondary schools. The study adopted the descriptive research design. The population of the study comprised all 7,767 teachers in Osun State secondary schools. The sample of 385 teachers was randomly selected. Two self-designed questionnaires were used. The data were analysed using Pearson Product Movement Correlation Statistics (PPMCS) at 0.05 level of significant. The findings showed that the use of Facebook (r = 0.692, df = 2071 & p<0.05), WhatsApp (r = 0.615, df = 2071 & p<0.05), Twitter (r = 0.542, df = 2071 & p<0.05), and Youtube (r = 0.461, df = 2071 & p<0.05) were significantly related to students’ academic performance of Osun State secondary schools. The study concluded that that the use of Facebook, WhatsApp, Twitter and Youtube among teachers and students had positive contributions to students’ academic performance of Osun State secondary schools. The findings implicate that the teachers and students in Osun State secondary schools and Nigeria at large should admire the use of social medial such as Facebook WhatsApp, Twitter and Youtube as an interactive forum for teaching-learning activities.