Neuroinflammation is known as the main mechanism implicated in the advancement of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. The main feature of neuroinflammation is associated with the activation of microglia. The activated microglia increase proinflammatory cytokine production and induce progressive neuronal cell death. Citrus flavonoids show neuroprotective effects that are associated with the anti-inflammatory action of flavonoids in neurodegenerative diseases. Among these citrus flavonoids, kaempferol, naringin, and nobiletin show inhibitory effects on nuclear factor-κB and mitogen-activated protein kinase signaling pathways that can modulate inflammatory conditions in microglial cells. In the present review, we present the anti-inflammatory activities of citrus flavonoids and therapeutic potential of flavonoids as neuroprotective agents.

Introduction
Flavonoids and Anti-neuroinflammation
    1. Flavonoids and major structures
    2. Anti-neuroinflammatory effects of citrus flavonoids
    3. Citrus flavonoids and oxidative stress
Molecular Mechanisms Underlying theAnti-neuroinflammatory Effects ofFlavonoids
Conclusions
References

• Heesu Lee(Department of Anatomy, College of Dentistry, Gangneung-Wonju National University)
• Baskar Selvaraj(Natural Product Research Center, Korea Institute of Science and Technology/Department of Biological Chemistry, University of Science and Technology)
• Ki Yeon Yoo(Department of Anatomy, College of Dentistry, Gangneung-Wonju National University) Correspondence to
• Seong-Hee Ko(Department of Pharmacology, College of Dentistry and Research Institute of Oral Science, Gangneung-Wonju National University) Correspondence to