Probiotics, such as Lactobacillus spp. and Bifidobacterium spp. are reported to have the multiple potential health benefits including blocking gastroenteric pathogens, reduce gut permeability, enhancing immune response and anti-viral effects. In this study, we explored whether LR211 and BL205, 206 exert on MCP-1 and IL-8 chemokines responses in rotavirus infected vero cells. And we investigated anti-rotaviral activity of Lactobacillus spp. and Bifidobacterium spp. isolated against rotavirus by plaque assay. As a results, all of them were not toxic to vero cells. Three probiotics, BL205, 206 and LR211, increased release of MCP-1 and IL-8 in Wa rotavirus infected vero cells compared to control. This anti-viral effects of LR211 and BL205, 206 can be explained that they modulate immune response by inducing MCP-1 and IL-8 chemokines.

Abstract
서 론
재료 및 방법
    세포주 및 배양 조건
    MTT assay
    Rotavirus 증식
    Plaque assay
    Interleukin-8의 분석
    Monocyte chemoattractant protein-1의 분석
결과 및 고찰
    세포독성 평가
    Rotavirus infection 및 titer 결정
    유산균 추출물에 의한 chemokine 변화 분석
References

• 최예진(덕성여자대학교 약학대학) | Yae Jin Choi (College of Pharmacy, Duksung Women’s University)
• 신혜순(덕성여자대학교 약학대학) | Hea Soon Shin (College of Pharmacy, Duksung Women’s University) Corresponding author