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로타바이러스 감염된 Vero 세포에서 Lactobacillus ruminus와 Bifidobacterium longum의 케모카인 변화 분석 KCI 등재후보

Chemokine Effects of Lactobacillus ruminus, and Bifidobacterium longum in Rotavirus Infected Vero Cells

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  • URLhttps://db.koreascholar.com/Article/Detail/397185
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Current Topic in Lactic Acid Bacteria and Probiotics (한국유산균·프로바이오틱스학회지)
한국유산균·프로바이오틱스학회 (Korean Society for Lactic Acid Bacteria and Probiotics)
초록

Probiotics, such as Lactobacillus spp. and Bifidobacterium spp. are reported to have the multiple potential health benefits including blocking gastroenteric pathogens, reduce gut permeability, enhancing immune response and anti-viral effects. In this study, we explored whether LR211 and BL205, 206 exert on MCP-1 and IL-8 chemokines responses in rotavirus infected vero cells. And we investigated anti-rotaviral activity of Lactobacillus spp. and Bifidobacterium spp. isolated against rotavirus by plaque assay. As a results, all of them were not toxic to vero cells. Three probiotics, BL205, 206 and LR211, increased release of MCP-1 and IL-8 in Wa rotavirus infected vero cells compared to control. This anti-viral effects of LR211 and BL205, 206 can be explained that they modulate immune response by inducing MCP-1 and IL-8 chemokines.

목차
Abstract
서 론
재료 및 방법
    세포주 및 배양 조건
    MTT assay
    Rotavirus 증식
    Plaque assay
    Interleukin-8의 분석
    Monocyte chemoattractant protein-1의 분석
결과 및 고찰
    세포독성 평가
    Rotavirus infection 및 titer 결정
    유산균 추출물에 의한 chemokine 변화 분석
References
저자
  • 신혜순(덕성여자대학교 약학대학) | Hea Soon Shin (College of Pharmacy, Duksung Women’s University) Corresponding author
  • 최예진(덕성여자대학교 약학대학) | Yae Jin Choi (College of Pharmacy, Duksung Women’s University)