According to the previous study, Lactobacillus pentosus A67 and L. plantarum subsp. plantarum C2 were isolated and screened. In this study, culture broths of strains A67 and C2 were performed various physiological activity assays including antimicrobial, antioxidant, cytotoxicity, cell proliferation activity. The remarkable anti-microbial activities using the culture broths of the two strains were showed by disc diffusion method, MIC tests. In the 2,2-diphenyl-1-picryl hydrazyl (DPPH) and superoxide dismutase (SOD) assays to verify antioxidant activity, culture broths of strains A67 and C2 significantly scavenged free radical maximum by 91.33% and 81.95% respectively compared with arbutin. Also, they showed equivalent activity same as 297.22 units and 255.56 units of SOD respectively. In RAW264.7 cells, culture broths of strain A67 and C2 showed no cytotoxicity. Moreover, they showed significant cell proliferative effects by 173.5% and 143.5% compared to control group respectively. Overall, this study showed that the culture broths of strain A67 and C2 had antimicrobial and antioxidant activities, which could synergically increase the physiological activities. And they had no cytotoxicity and cell proliferative effects. Therefore, it is expected that L. pentosus A67 and L. plantarum C2 could be applied to a wide variety of functional materials including food and medicine as new probiotics.

Abstract
서 론
재료 및 방법
    세포주 및 지시균주
    생리활성 검토
결과 및 고찰
    항균활성 검토
    항산화 활성 검토
    면역활성 및 세포독성 검사
요 약
References

• 추동훈(콜마비앤에이치) | Donghun Chu (Kolmarbnh)
• 국무창(배화여자대학교 식품영양과) | Moochang Kook (Dept. of Food & Nutrition, Baewha Women’s University) Corresponding author