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pp.837-846
In present study, we investigated the antidiabetic effect of Momordica charantia(as well known “bitter melon”). This study was conducted to determine antidiabetic mechanism of Bitter Melon Extract (BME). We measured blood glucose, insulin, glucagon level in a Sprague-Dawley rat model of high-fat diet/streptozotocin(HFD/STZ)-induced diabetes. Five experimental groups were used: normal, HFD/STZ, BME 62.5 mg/kg HFD/STZ, BME 125 mg/kg HFD/STZ and BME 250 mg/kg HFD/STZ. BME was orally administered to the rats every other day for 9 weeks. Results showed that fasting blood glucose levels were significantly lower in the BME 125 mg/kg(150.17 ± 20.22 mg/dL) and 250 mg/kg(124.17 ± 22.17 mg/dL) groups than in the vehicle group(188.83 ± 26.63 mg/dL)(p<0.05). In addition, glucagon levels were lower in the three BME treatment groups than in the vehicle group(p<0.05). Oral glucose tolerance tests revealed that the BME 250 mg/kg group had significantly(p<0.05) reduced 120-minute blood glucose levels and areas under the curve. Our results suggest that BME induces antidiabetic effects via the reduction of glucagon and blood glucose levels.
1. 서 론
2. 재료 및 방법
2.1. 투여 시료의 제조
2.2. 당뇨 유발
2.3. 군분리 및 일반 증상 관찰
2.4. 절식 혈당
2.5. 당화혈색소(HbA1c) 측정
2.6. 혈중 Insulin, Glucagon 측정
2.7. 경구 당부하 시험
2.8. 조직학적 검경 분석
2.9. 통계 처리
3. 결과 및 고찰
3.1. 미숙여주주정추출분말의 경구투여로 인한 혈당조절 효과
3.2. 미숙여주주정추출분말의 경구투여로 인한 혈중glucagon 및 insulin 농도 변화
3.3. 미숙여주주정추출분말의 경구투여가 경구당부하검사에 미치는 영향
3.4. 미숙여주주정추출분말 경구투여에 의한 당화혈색소함량 변화
3.5. 미숙여주주정추출분말 경구투여로 인한 췌장의조직학적 변화
4. 결 론
REFERENCES
