Self-efficacy has been extensively evaluated, but no studies have investigated the effect of self-efficacy on the self-reliance of women in poor-households economic productivity. This study analyzes self-efficacy as a personal factor, learning processes, and social support as an environmental factor towards the achievement of self-reliance in women from poor-households in productive economy businesses. Despite the dominant logic of this scheme, there is a need for field-based data regarding whether the variable really supports the sustainable empowerment of poor-households women. This study used the quantitative method through the survey technique. The samples of this study included 250 people collected from five regencies in Indonesia by using a multiple-stage random sampling. The data were analyzed with structural equation modeling. The results show that social support has a significant positive impact on the learning process; social support has a direct negative impact on self-efficacy. The learning process has a direct positive influence on self-efficacy, while social support has a non-significant impact on self-reliance. The learning process has a direct influence on self-reliance. Social support and the learning process both have significant positive impact on self-efficacy. Social support, learning process, and self-efficacy simultaneously have a positive impact on self-reliance in productive economic activities.