Based on the panel data of 24 provinces (cities) in mainland China over 19 years from 2000 to 2018, this paper analyzes the macro factors influencing South Korea's direct investment in China. The analysis results show that the GDP size of Chinese provinces (cities) has attracted the inflow of direct investment from South Korea significantly. Infrastructure construction in each province (city) is also an influential factor. The market openness, FDI acceptance and technology market activity of Chinese provinces (cities) are also the reasons that have a significant impact on South Korean FDI. In addition, South Korea's direct investment in China also has a positive effect in terms of the investment cost reduction brought by borrowing financing and currency exchange rate. Finally, the financial crisis has slowed South Korea's direct investment in China. In terms of geographical selection, South Korea's direct investment tends to the eastern developed regions.