Streptozotocin(STZ)을 45mg/kg.b.w의 용량으로 흰쥐의 미정맥에 투여 한 후 당뇨병이 유발된 당뇨 흰쥐에게 1일 1회 7일간 1,000mg/kg,b.w의 용량으로 황백에탄올 추출물을 투여 후 glucose 함량과 당대사에 관여하는 효소인 glucose-6-phosphatase(G-6-Pase), glucose-6-phosphate dehydrogenase(G-6-PDH, glucokinase(GK)활성과 glycogen 함량을 측정한 결과 황백 에탄올 추출물 투여군이 glucose 함량과 G-6-Pase 활성의 유의적인 감소를 나타내었으며 glycogen 함량과 G-6-PDH, GK의 활성은 유의적인 증가를 나타내었다. 이와 같이 황백 에탄올 추출물이 혈당강하 효과를 가졌다.

This study was performed to investigate the antidiabetic effect of ethanol extract of Phelladrindron Amurense Rupr (P.A) in Streptozotocin(STZ) induced diabetic rats. Diabetes was induced by intravenous injection of STZ at a dose of 45㎎/㎏,b.w. dissolved in citrate buffer. The ethanol extract of P. A was orally administrated once a day for 7 days at a dose of 1,000㎎/㎏. The content of serum glucose, was significantly decreased in P.A treated group compared to the those of STZ-control group. The content of hepatic glycogen and activities of glucokinase(GK) and glucose-6-phosphate dehydrogenase(G-6-PDH) were significantly increased(p<0.05), and activity of glucose-6-phoshatase(G-6-Pase) was significantly decreased(p<0.05) in P.A treated group compared to those of STZ-control group, These results indicated that ethanol extract of P.A have antidiabetic effect in STZ-induced diabetic rats.

요 약
Abstract
1. 서 론
2. 실 험
    2.1. 시료, 시약 및 기기
    2.2. 추출 실험
    2.3. 실험동물사육, 당뇨유발 및 검액의 조제
    2.4. 효소원 조제 및 분석
    2.5. 통계처리
3. 결과 및 고찰
    3.1. Ethanol 추출물의 수율
    3.2. 혈당 저하 효과
    3.3. 간 조직중의 Glycogen 함량
    3.4. 간 조직중의 Glucose-6-phosphatase(G-6-Pase) 활성
    3.5. 간 조직중의 Glucose-6-phosphatedehydrogenase(G-6-PDH)활성
    3.6. 간 조직중의 Glucokinase(GK) 활성
4. 결 론
References

• 김옥경(대진대학교 과학기술대학 식품영양학과) | Ok-Kyung Kim (Department of Food Science and Nutrition, Dae Jin University) Corresponding author