This study evaluated the antimicrobial activity of Endoseal TCS, an mineral trioxide aggregate-based root canal sealer, mixed with water-soluble mangostin derivatives (WsMD) of Garcinia mangostana L. (mangosteen) ethanol extract against Enterococcus faecalis and Staphylococcus aureus. The antibacterial activity of Endoseal TCS mixed with WsMD against three strains of E. faecalis and three strains of S. aureus was performed using agar diffusion test. The data showed that Endoseal TCS mixed with 0.115% WsMD had a zone of inhibition of 0.7 ± 0.2–2.4 ± 0.1 mm. The results suggest that Endoseal TCS mixed with WsMD of Garcinia mangostana L. ethanol extract is useful as a root canal sealer with antibacterial activity against E. faecalis and S. aureus .

Introduction
Materials and Methods
    1. Bacteria and bacterial cultur
    2. Preparation of water-soluble mangostin derivativepowder
    3. Preparation of mixed sample of WsMD powder andEndoseal TCS®
    4. Antibacterial test
Results
Discussion
References

• Tae-Young Park(Department of Conservative Dentistry, Chosun University)
• Yun Kyong Lim(Korean Collection for Oral Microbiology, Chosun University/Department of Oral Biochemistry, School of Dentistry, Chosun University)
• Jin-Hee Kim(Department of Oral Biochemistry, School of Dentistry, Chosun University/Medi Bio Lab Co., Ltd.)
• Dae Sung Lee(Medi Bio Lab Co., Ltd.) Correspondence to
• Joong-Ki Kook(Korean Collection for Oral Microbiology, Chosun University/Department of Oral Biochemistry, School of Dentistry, Chosun University) Correspondence to