This study summarizes the recent cutting-edge approaches for dentin regeneration that still do not offer adequate solutions. Tertiary dentin is formed when odontoblasts are directly affected by various stimuli. Recent preclinical studies have reported that stimulation of the Wnt/β-catenin signaling pathway could facilitate the formation of reparative dentin and thereby aid in the structural and functional development of the tertiary dentin. A range of signaling pathways, including the Wnt/β-catenin pathway, is activated when dental tissues are damaged and the pulp is exposed. The application of small molecules for dentin regeneration has been suggested as a drug repositioning approach. This study reviews the role of Wnt signaling in tooth formation, particularly dentin formation and dentin regeneration. In addition, the application of the drug repositioning strategy to facilitate the development of new drugs for dentin regeneration has been discussed in this study.

Structure and Function of Dentin
Wnt Signalings in Tooth Formation
Recent Studies in RegenerativeEndodontics
    1. Cell transplantation and homing
    2. Pulp revascularization
    3. Tertiary dentin formation using Wnt/β-cateninsignaling
    4. Reparative dentin formation using drugrepositioning
Conclusions
References

• Eui-Seon Lee(Department of Biochemistry, School of Dentistry, Institute for Hard Tissue and Bio-tooth Regeneration (IHBR), Kyungpook National University)
• Tae-Young Kim(Department of Biochemistry, School of Dentistry, Institute for Hard Tissue and Bio-tooth Regeneration (IHBR), Kyungpook National University)
• Yam Prasad Aryal(Department of Biochemistry, School of Dentistry, Institute for Hard Tissue and Bio-tooth Regeneration (IHBR), Kyungpook National University)
• Kihyun Kim(Department of Biochemistry, School of Dentistry, Institute for Hard Tissue and Bio-tooth Regeneration (IHBR), Kyungpook National University)
• Seongsoo Byun(Department of Biochemistry, School of Dentistry, Institute for Hard Tissue and Bio-tooth Regeneration (IHBR), Kyungpook National University)
• Dongju Song(Department of Biochemistry, School of Dentistry, Institute for Hard Tissue and Bio-tooth Regeneration (IHBR), Kyungpook National University)
• Yejin Shin(Department of Biochemistry, School of Dentistry, Institute for Hard Tissue and Bio-tooth Regeneration (IHBR), Kyungpook National University)
• Dany Lee(Department of Biochemistry, School of Dentistry, Institute for Hard Tissue and Bio-tooth Regeneration (IHBR), Kyungpook National University)
• Jooheon Lee(Department of Biochemistry, School of Dentistry, Institute for Hard Tissue and Bio-tooth Regeneration (IHBR), Kyungpook National University)
• Gilyoung Jung(Department of Biochemistry, School of Dentistry, Institute for Hard Tissue and Bio-tooth Regeneration (IHBR), Kyungpook National University)
• Seunghoon Chi(Department of Biochemistry, School of Dentistry, Institute for Hard Tissue and Bio-tooth Regeneration (IHBR), Kyungpook National University)
• Yoolim Choi(Department of Biochemistry, School of Dentistry, Institute for Hard Tissue and Bio-tooth Regeneration (IHBR), Kyungpook National University)
• Youngkyun Lee(Department of Biochemistry, School of Dentistry, Institute for Hard Tissue and Bio-tooth Regeneration (IHBR), Kyungpook National University)
• Chang-Hyeon An(Department of Oral and Maxillofacial Radiology, School of Dentistry, IHBR, Kyungpook National University) Correspondence to
• Jae-Young Kim(Department of Biochemistry, School of Dentistry, Institute for Hard Tissue and Bio-tooth Regeneration (IHBR), Kyungpook National University) Correspondence to