Helicobacter (H.) pylori is one of the most common pathogenic bacteria in the human gut, and is also one of the most important factors that cause digestive disorders such as chronic inflammation, gastric ulcers, and even gastric cancer. Since the use of various antibiotics to treat H. pylori infection is associated with the development of resistance in this bacterium, the aim of this study was to determine the anti-H. pylori effects of Peucedanum japonicum extracts (PJE) in the stomach tissue of C57BL/6 mice. In this experimental study, 50 C57BL/6 mice in five groups were evaluated. After induction of H. pylori infection in mice with the standard strain of H. pylori (ATCC 43504), the infected mice were treated with 3 different doses of PJE in different groups. Then, the anti-H. pylori effects of PJE were evaluated by rapid urease test (CLO), histopathological exam and blood interleukin (IL)-8 ELISA analysis. Based on CLO results, H. pylori eradication effects of PJE was observed. H. pylori infection of C57BL/6 mice showed significant increase of histopathological lesion scores. However, the treatment of PJE showed significant decrease of histopathological lesion scores. The treatment of PJE decreased gastric inflammation and mucosal lesions in the stomach of H. pylori-infected mice. Blood IL-8 levels were elevated 4 weeks after H. pylori inoculation. However, the treatment of PJE showed significant decrease of IL-8 level. According to the results of this study, PJE could be useful in the reduction of H. pylori infection in the mouse model.

Abstract
서 론
재료 및 방법
    갯기름나물 추출 시험 물질
    실험동물
    H. pylori 배양 및 감염 유발
    군구성
    CLO 신속요소분해효소 검사
    위점막 병리조직학적 검사
    혈중 Interleukin 8검사
    통계학적 분석
결 과
    CLO 신속요소분해효소 검사 결과
    병리조직학적 점수
    Interleukin 8(IL-8) 검사 결과
고 찰
REFERENCES

• Hyung-Suk Lee(Division of Companion Animal Science, Woosong College)
• Okjin Kim(Center for Animal Resources Development, Wonkwang University) Corresponding Author