The present study is designed to investigate the hypolipidemic effect of the hot-water extract from the leaves of Dendropanax morbifera L. (DMWE) in hyperlipidemic rats. Thirty male 5-week-old rats were grouped as follows: Normal control (NC) given distilled water; hyperlipidemic control (HC) administered with distilled water; drug treatment (DT) orally administered with atorvastatin (10 mg/kg body weight (BW)); DMWE-treated groups (DM-50, DM-100 and DM-200) treated with DMWE 50, 100 and 200 mg/kg BW, respectively. All groups (except for NC) were fed a high-fat diet during the experiment. After 4 weeks of administration, the BW of all groups treated with DMWEs significantly increased compared to that of HC (p<0.05) and showed no significant difference compared to that of NC. In addition, serum total cholesterol levels in all groups treated with DMWEs were meaningfully decreased, compared to that in HC (p<0.05). In serum triglyceride (TG) and low-density lipoprotein-cholesterol levels, both DM-100 and DM-200 considerably decreased compared to HC (p<0.05), and no significant differences in TG levels were between DM-100 and DM-200. In high-density lipoprotein-cholesterol levels, DM-200 was statistically different compared to HC, and there were no significant differences between DM-100, DM-200 and DT. Furthermore, aspartate transaminase and alanine aminotransferase concentrations of DM-100 and DM-200 were significantly decreased compared to those of HC (p<0.05). From results portrayed above, DMWE at the concentration of 100 mg/kg BW has been identified to be effective in the treatment of hyperlipidemic rats.

Abstract
서 론
재료 및 방법
    실험재료
    실험동물
    시험군 구성 및 약제 투여
    실험동물 고지혈증 유발 식이
    체중측정
    혈액체취 및 분석
    통계학적 분석
결 과
    체중변화
    혈중 지질 농도
    혈청 중 AST와 ALT 농도
고 찰
REFERENCES

• Ye-Jin Kang(Department of Environmental Health, Graduate School of Public Health, Gyeongsang National University)
• Min-Jae Kim(Department of Environmental Health, Graduate School of Public Health, Gyeongsang National University)
• Jin-Hyeok Kim(Department of Anesthesiology and Pain Medicine, College of Medicine, Inje University)
• Yongjae Han(Department of Anesthesiology and Pain Medicine, College of Medicine, Inje University)
• Kwang-Il Park(Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
• Suk Kim(Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
• Hu-Jang Lee(Department of Environmental Health, Graduate School of Public Health, Gyeongsang National University/Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) Corresponding Author