Currently, the construction trend of high-rise structures is changing from a cube-shaped box to a free-form. In the case of free-form structures, it is difficult to predict the behavior of the structure because it induces torsional deformation due to inclined columns and the eccentricity of the structure by the horizontal load. For this reason, it is essential to review the stability by considering the design variables at the design stage. In this paper, the position of the weak vertical member was analyzed by analyzing the behavior of the structure according to the change in the core position of the twisted high-rise structures. In the case of the shear wall, the shear force was found to be high in the order of proximity to the center of gravity of each floor of the structure. In the case of the column, the component force was generated by the axial force of the outermost beam, so the bending moment was concentrated on the inner column with no inclination.