Background : Mucoepidermoid carcinoma (MEC) is the most common primary epithelial malignant salivary gland tumor in both adults and children. Histological grading of MEC is subjective, but plays an important role in predicting patient prognosis. Immunohistochemistry can accurately diagnose diseases and help with treatment and prognosis. The review of this paper was intended to be helpful in the differential diagnosis of mucinous epidermoid carcinoma. Methods : A PubMed search was carried out. Well-known biomarkers for mucoepidermoid carcinoma were searched in PubMed, and their differences with oral squamous cell carcinoma were compared. Results : When PubMed searched “oral mucoepidermoid carcinoma, biomarker”, a total of 241 papers were found, among which cytokeratin(22), Muc1(membrane-bound mucin1, 9), Muc4( membrane-bound mucin4, 6), Muc5ac (membrane-bound mucin5ac, 4), Muc5b (membrane-bound mucin5b, 3), p63 (15), PCNA (15), p53 (20), EGFR (Epidermal growth factor receptor, 21), c-erbB2 (HER2, 14), and pAKT (2) were searched and investigated. The biomarkers retrieved above were compared with those expressed in squamous cell carcinoma. Conclusion : Due to the above biomarkers, it is possible to classify mucoepidermoid carcinoma and differentiate it from other salivary gland tumors or oral squamous cell carcinoma.

Ⅰ. INTRODUCTION
Ⅱ. Materials and Methods
Ⅲ. RESULTS
Ⅳ. DISCUSSION
    1. cytokeratin
    2. membrane-bound mucins, including MUC1,MUC4, MUC5AC and MUC5B
    3. p63
    4. PCNA, p53
    5. epidermal growth factor receptor (EGFR;ErbB-1; HER1 in humans)
    6. pAKT
Ⅴ. CONCLUSION
REFERENCES

• 이상신(강릉원주대학교 치과대학 구강병리학교실) | Sang Shin Lee (Department of Oral Pathology, College of Dentistry, Gangneung-Wonju National University, Gangneung, Korea) Corresponding author