This study investigated the seismic performance of reinforced concrete (RC) wall-slab frames with masonry infills. Four RC wall-slab frames with or without masonry infill were tested under cyclic loading. The RC frames were composed of in-plane and out-of-plane walls and top and bottom slabs. For masonry infill walls, cement bricks were stacked applying mortar paste only at the bed joints, and, at the top, a gap of 50 mm was intentionally left between the masonry wall and top RC slab. Both sides of the masonry walls were finished by applying ordinary or fiber-reinforced mortars. The tests showed that despite the gap on top of the masonry walls, the strength and stiffness of the infilled frames were significantly increased and were different depending on the direction of loading and the finishing mortars. During repeated loading, the masonry walls underwent horizontal and diagonal cracking and corner crushing/spalling, showing a rocking mode inside the RC wall-slab frame. Interestingly, this rocking mode delayed loss of strength, and as a result, the ductility of the infilled frames increased to the same level as the bare frame. The interaction of masonry infill and adjacent RC walls, depending on the direction of loading, was further investigated based on test observations.