This study aimed to examine cucumber (Cucumis sativus) varieties adaptive to the desert climate by comparing and analyzing the growth, yield, and water consumption. Two long-sized cucumber varieties, ‘Gulfstream’ and ‘Imea’ and two medium-sized cucumbers, ‘Nagene’ and ‘Sausan’ were cultivated in coir substrate hydroponics under hot and humid greenhouse conditions from March 2 to June 20, 2020. On the 113 DAT, ‘Nagene’ had the longest plant height and the highest internode number. The marketable fruit number per plant was higher in the medium-sized varieties, which had more internode number. The marketable fruit number was 31.3 for ‘Gulfstream’, 30.7 for ‘Imea’, 57.8 for ‘Nagene’, or 56.0 for ‘Sausan’ with no significant difference in total fruit weights per plant. The water consumption required to produce 200 g of fruit was lower in the ‘Nagene’ (2.39 L) with the highest water use efficiency (WUE). Therefore, ‘Nagene’ variety may have higher adaptability to desert high temperature compared to the long-sized varieties, and it is going to be necessary to verify more medium-sized cucumber varieties.