Stem cells are progenitor cells that are capable of self-renewal and differentiation into various cells. Especially, pluripotent stem cells (PSCs) have in vivo and in vitro differentiation capacity into three germ layers and can proliferate infinitely. The differentiation ability of PSCs can be applied for regenerative medicine and tissue engineering. In domestic animals, their PSCs have a potential for preclinical therapy as well as the production of transgenic animals and agricultural usage such as cultured meat. Among several domestic animals, a pig is considered as an ideal model for biomedical and agricultural purposes mentioned above. In this reason, studies for pig PSCs including embryonic stem cells (ESCs), embryonic germ cells (EGCs) and induced pluripotent stem cells (iPSCs) have been conducted for decades. Therefore, this review will discuss the history of PSCs derived from various origins and recent progress in pig PSC research field.

ABSTRACT
INTRODUCTION
BEGINNING OF PLURIPOTENT CELLRESEARCH
EMBRYONIC STEM CELLS (ESCs)
EPIBLAST STEM CELLS (EpiSCs)
EMBRYONIC GERM CELLS (EGCs)
INDUCED PLURIPOTENT STEM CELLS (iPSCs)
LARGE ANIMAL MODELS IN STEM CELLBIOLOGY: A PIG REVIEW
PERSPECTIVES
CONFLICTS OF INTEREST
ACKNOWLEDGEMENTS
ORCID
REFERENCES

• Kwang-Hwan Choi(Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute of Agriculture and Life Science, Seoul National University, Seoul 08826, Korea)
• Chang-Kyu Lee(Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute of Agriculture and Life Science, Seoul National University, Seoul 08826, Korea, Institute of Green Bio Science and Technology, Seoul National University, Pyeongchang 25354, Korea) Corresponding author