Mutations in the luteinizing hormone/chorionic gonadotropin receptors (LH/CGRs), representatives of the G protein-coupled receptor family, have been rapidly identified over the last 20 years. This review aims to compare and analyze the data reported the activating and inactivating mutations of the LH/CGRs between human, rat, equine and fish, specifically (Japanese eel Anguilla japonica). Insights obtained through detailed study of these naturally-occurring mutations provide a further update of structure-function relationship of these receptors. Specifically, we present a variety of data on eel LH/CGR. These results provide important information about LH/CGR function in fish and the regulation of mutations of the highly conserved amino acids in glycoprotein hormone receptors.

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• Kwan-Sik Min(Institute of Genetic Engineering, Hankyong National University,Department of Animal Biotechnology, Graduate School of Hankyong National University,Department of Animal Life Science, Hankyong National University,) Corresponding author
• Munkhzaya Byambaragchaa(Institute of Genetic Engineering, Hankyong National University, Ansung 17579, Korea)
• Seung-Hee Choi(Department of Animal Biotechnology, Graduate School of Hankyong National University, Ansung 17579, Korea)
• Hyo-Eun Joo(Department of Animal Life Science, Hankyong National University, Ansung 17579, Korea)
• Sang-Gwon Kim(Department of Animal Life Science, Hankyong National University, Ansung 17579, Korea)
• Yean-Ji Kim(Department of Animal Life Science, Hankyong National University, Ansung 17579, Korea)
• Gyeong-Eun Park(Department of Animal Life Science, Hankyong National University, Ansung 17579, Korea)