When picking up cargo, workers manually load and unload the cargo. Workers have different intensity of work depending on the amount and weight of cargo. In particular, as the intensity of manual work increases, workers are exposed to cumulative traumatic diseases. A manual for picking safety work for workers cargo handling in the distribution center is required. In this study, the worker’s picking safety work based on the cargo volume and weight was presented as an experimental design model. Like the research results, the disease begins when the worker feels the number of pains presented by the model.