Toxohormone-L is a lipolytic factor, found in ascites fluid of sarcoma 180-bearing mice and of patients with hepatoma. A substance that inhibited the lipolytic action of Toxohormone-L was isolated and purified from Korean red ginseng powder. This substance had a pectin-like a 1, 4-polygalacturonan backbone with some acetoxyl groups, and so was an acidic polysaccharide. It inhibited Toxohormone-L induced liploysis in a dose dependent manner at concentrations higher than 10㎍/㎖. Purified acidic polysaccharide yield(PG_4-3 and PG_4-4 fraction) was about 0.03%. And also pectic acid that inhibited the lipolytic action of Toxohormone -L.