논문 상세보기
pp.296-308
This study investigated the anti-obesity effects of Coriandrum sativum L. ethanol extracts in a high fat diet-induced obesity model (DIO). We confirmed the anti-obesity effects by analysing the expression of the related proteins, weight gain, dietary intake, dietary efficiency, blood biochemistry, histological analysis and western blot analysis. After oral administration of Coriandrum sativum L. ethanol extracts at concentrations of 250 and 500 mg/kg, a significant improvement in dietary efficiency, reduction in weight gain, triglycerides, total cholesterol and LDL-cholesterol in blood lipid was observed for 8 weeks. In addition, improvement in blood glucose and metabolism confirmed through glucose tolerance test was observed. Further, the concentration of alanine transaminase (ALT) in blood was significantly decreased, which improved the fatty liver caused by high-fat diet intake as confirmed by liver tissue analysis. This phenomenon was confirmed to decrease the expression of fat accumulation-related PPARγ and FAS protein in the liver tissue. Especially, it is believed that FAS, a liposynthetic enzyme, has a stronger inhibitory effect than PPARγ. Therefore, Coriandrum sativum L. ethanol extract is thought to improve obesity by reducing blood lipids levels, improving glucose metabolism and inhibiting synthesis of the fat that accumulates in the liver in high-fat diet-induced obesity animal models.
서 론
재료 및 방법
1. 시험물질제조
2. 실험동물 사육조건
3. 고지방식이로 유도된 비만 동물모델
4. 혈액 및 시료채취
5. Western blot 실험
6. 조직의 병리학적 표본 제작, 염색 및 관찰
7. 통계 분석
결과 및 고찰
1. 체중, 식이섭취량 및 식이효율 변화
2. 지방조직 무게의 변화
3. 장기무게의 변화
5. 혈중 생화학지표 농도
6. 동물의 간, 췌장, 지방조직의 변화
7. 동물의 부고환지방에서 지방축적 관련 단백질의 발현
요약 및 결론
References
