Iron oxide (Fe2O3) nanoclusters exhibit significant potential in the biomedical and pharmaceutical fields due to their strong magnetic properties, stability in solutions, and compatibility with living systems. They excel in magnetic separation processes, displaying high responsiveness to external magnetic fields. In contrast to conventional Fe2O3 nanoparticles that can aggregate in aqueous solutions due to their ferrimagnetic properties, these nanoclusters, composed of multiple nanoparticles, maintain their magnetic traits even when scaled to hundreds of nanometers. In this study, we develop a simple method using solvothermal synthesis to precisely control the size of nanoclusters. By adjusting precursor materials and reducing agents, we successfully control the particle sizes within the range of 90 to 420 nm. Our study not only enhances the understanding of nanocluster creation but also offers ways to improve their properties for applications such as magnetic separation. This is supported by our experimental results highlighting their size-dependent magnetic response in water. This study has the potential to advance both the knowledge and practical utilization of Fe2O3 nanoclusters in various applications.

1. Introduction
2. Experimental
    2.1 사용 재료
    2.2 산화철 나노클러스터 합성
    2.3 산화철 나노클러스터 자기 영동 측정
3. Results and Discussion
    3.1 반응물 농도에 따른 산화철 나노클러스터 합성
    3.2 반응 용액의 염기도에 따른 산화철 나노클러스터의크기 제어
    3.3 산화철 나노클러스터 크기별 자기 영동
4. Conclusion

• 이상훈(한밭대학교 화학생명공학과) | Sanghoon Lee (Department of Chemical and Biological Engineering, Hanbat National University, Daejeon 34158, Republic of Korea)
• 변아림(한밭대학교 화학생명공학과) | Arim Byun (Department of Chemical and Biological Engineering, Hanbat National University, Daejeon 34158, Republic of Korea)
• 최진실(한밭대학교 화학생명공학과) | Jin-sil Choi (Department of Chemical and Biological Engineering, Hanbat National University, Daejeon 34158, Republic of Korea) Corresponding Author