Background: A decrease in physical activity has been observed due to the global pandemic, resulting in the onset and progression of musculoskeletal disorders as chronic diseases. Objectives: This study aimed to assess the difference in the degree of contraction of the lower limb muscles between the existing vertical vibration method and a new cross-vibration method. Design: Randomized controlled trial. Methods: The exercise program using whole-body vibration equipment was conducted for 12 sessions, 25 min per session, three times per week for 4 weeks. Results: The changes over time showed a significant difference in cross-alternating vibrations (P<.05), except for the lateral gastrocnemius and tibialis anterior, with no significant difference in sonic vertical vibration (P>.05). The interaction between time and group was significant for all muscles (P<.05), except for the biceps femoris, with differences between before the program and at 2 and 4 weeks after the program revealed in the post-hoc analysis. Conclusion: Future studies should further evaluate the use of CAV exercise devices as auxiliary equipment in exercise by assessing different groups and variations in intensity.