This study proposes a methodology for the regional seismic risk assessment of structural damage to buildings in Korea based on evaluating individual buildings, considering inconsistency between the administrative district border and grid lines to define seismic hazard. The accuracy of seismic hazards was enhanced by subdividing the current 2km-sized grids into ones with a smaller size. Considering the enhancement of the Korean seismic design code in 2005, existing seismic fragility functions for seismically designed buildings are revised by modifying the capacity spectrum according to the changes in seismic design load. A seismic risk index in building damage is defined using the total damaged floor area considering building size differences. The proposed seismic risk index was calculated for buildings in 29 administrative districts in 'A' city in Korea to validate the proposed assessment algorithm and risk index. In the validation procedure, sensitivity analysis was performed on the grid size, quantitative building damage measure, and seismic fragility function update.