This study aimed to determine the anti-obesity effect of adding Wolfiporia extensa Ginns (W) to fermented pollack skin products in an obesity-induced animal model. The experimental groups were the normal diet group (C), high-fat diet group (HF), dried pollack skin (H1), fermented pollack skin (H2), and W of 0.1 (F2-WL), 0.3 (F2-WM), and 0.5 (F2), respectively. It was confirmed that adding W to fermented pollack skin reduced blood triglycerides, total cholesterol, and LDL levels, while increasing HDL levels. Wolfiporia extensa Ginns was effective in controlling weight and improving blood lipids in a dose-dependent manner. In histological analysis, findings of fatty liver induced by a high-fat diet were improved by the addition of H2 and W. Size and density of fat globules in the epididymis were decreased. In addition, the concentration of TNF-α was increased in the high-fat diet group, but decreased by the addition of fermented pollack skin and W. In conclusion, adding fermented dried pollack skin and Wolfiporia extensa Ginns was effective for weight control and blood lipid improvement. Thus, the use of by-products in functional foods is expected to have a high value in the future.

서 론
재료 및 방법
    1. 시험물질 제조 방법
    2. 실험동물 사육조건 및 고지방식이 비만동물모델
    3. 혈액 및 시료채취
    4. 혈청 생화학 분석(biochemistry)
    5. 조직의 병리학적 표본 제작 후 염색 및 관찰
    6. 통계 분석
결과 및 고찰
    1. 체중 및 칼로리 섭취량의 변화
    2. 식이효율의 변화
    3. 장기무게의 변화
    4. 지방조직의 무게변화
    5. 혈중 지질의 변화
    6. 혈중 생화학지표 변화
    7. 동물의 조직학적 병리 검사 및 형태학적 변화
요약 및 결론

• 김미자(호서대학교 보건산업연구소 연구원) | Mi Ja Kim (Researcher, Institute of Health Industry, Hoseo University, Seoul 06724, Korea)
• 강순아(호서대학교 벤처대학원 융합공학과 교수, 호서대학교 보건산업연구소 소장) | Soon Ah Kang (Professor, Dept. of Convergence Technology, Graduate School of Venture, Hoseo University, Seoul 06724, Korea, Director, Institute of Health Industry, Hoseo University, Seoul 06724, Korea) Corresponding author