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Effect of Alpha Lipoic Acid and Pyridine Group on Silicone Hydrogel Lens KCI 등재

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대한시과학회지 (The Korean Journal of Vision Science)
대한시과학회 (The Korean Society Of Vision Science)
초록

Abstract Purpose : In this study, α-Lipoic acid and pyridine were added to hydrogel materials and silicone hydrogel materials, respectively, to manufacture contact lens to evaluate changes in physical properties. Methods : N,N-Dimethylacrylamide (DMA), 2,2'-Azobis (2-methylpropionitrile) (AIBN), an initiator, and Ethylene glycol dimethacrylate (EGDMA), crosslinking agent, were used basic mixing ratio, and hydrogel materials were prepared by thermopolymerization at 100°C for 1 hour based on 2-Hydroxyethyl methacrylate (HEMA). Silicone hydrogel materials were prepared by thermopolymerization at 130°C for 2 hours based on Silicone monomer (SID). The properties of contact lenses were evaluated by adding 0.05% of 3-hydroxypyridine N-oxide and (R)-(+)-α-Lipoic acid by ratio to each material. Results : A lens manufactured by adding alpha lipoic acid to silicone hydrogel materials showed a tendency to increase wettability and decrease refractive index. A lens manufactured by adding pyridine to silicone hydrogel materials showed UV-A blocking ability, and the refractive index tended to increase. In addition, a contact lens manufactured by adding alpha lipoic acid and pyridine together showed antimicrobial properties, reduced surface roughness, and increased wettability and oxygen permeability according to the ratio of alpha lipoic acid addition. Conclusion : It is judged that alpha lipoic acid and pyridine are expected to improve wettability and oxygen permeability of the lens and to be used as contact lens materials with antibacterial properties. Key words : Alpha lipoic acid, Antimicrobial, Oxygen permeability, Pyridine, Wettability

목차
Ⅰ. Introduction
Ⅱ. Materials and Methods
    1. Reagents and Materials
    2. Polymerization
    3. Analysis
Ⅲ. Results
    1. Properties of Alpha Lipoic Acid
    2. Properties of Pyridine
    3. Properties of Alpha Lipoic Acid PyridineCombination
Ⅳ. Discussion
Ⅴ. Conclusion
References
저자
  • Seon-Young Park(Dept. of Optometry & Vision Science, Daegu Catholic University, Student, Daegu)
  • A-Young Sung(Dept. of Optometry & Vision Science, Daegu Catholic University, Professor, Daegu) Corresponding author