Purpose: The purpose of this study is to understand the nature of the health promotion behavior of the high-risk group of cardiovascular disease among large-scale industrial manufacturing workers. Method: The subjects of this study were 11 workers at high-risk of cardiovascular disease with a Framingham Risk Score (FRS) score of 10% or more among workers at large-scale workplace in Gyeongsangbukdo area, and the data collection period is from July 1 to September 11, 2022. The interview data were inductively analyzed using the qualitative content analysis method used by Elo and Kyngas (2008). Result: Participants' awareness of their own health status and knowledge of cardiovascular disease were low, and there were more obstacles than benefits to health behavior. The process and method of realizing and practicing health care were also different. As a result of qualitative content analysis, 42 semantic units, 12 subcategories, and 3 upper categories were derived. The health promotion behavior of workers at high-risk for cardiovascular disease was categorized into ‘Awareness of health conditions’, ‘Obstacles to health care behavior’, ‘Health care practice process’. Conclusion: Since most of the workers spend a lot of time at work, it is necessary to understand the health care of high-risk workers with cardiovascular disease, so a qualitative study using participatory observation methods to observe workers’ work sites is recommended.