The most important thing in development of a process-based TSPA (Total System Performance Assessment) tool for large-scale disposal systems (like APro) is to use efficient numerical analysis methods for the large-scale problems. When analyzing the borehole in which the most diverse physical phenomena occur in connection with each other, the finest mesh in the system is applied to increase the analysis accuracy. Since thousands of such boreholes would be placed in the future disposal system, the numerical analysis for the system becomes significantly slower, or even impossible due to the memory problem in cases. In this study, we propose a tractable approach, so called global-local iterative analysis method, to solve the large-scale process-based TSPA problem numerically. The global-local iterative analysis method goes through the following process: 1) By applying a coarse mesh to the borehole area the size of the problem of global domain (entire disposal system) is reduced and the numerical analysis is performed for the global domain. 2) Solutions in previous step are used as a boundary condition of the problem of local domain (a unit space containing one borehole and little part of rock), the fine mesh is applied to the borehole area, and the numerical analysis is performed for each local domain. 3) Solutions in previous step are used as boundary conditions of boreholes in the problem of global domain and the numerical analysis is performed for the global domain. 4) steps 2) and 3) are repeated. The solution derived by the global-local iterative analysis method is expected to be closer to the solution derived by the numerical analysis of the global problem applying the fine mesh to boreholes. In addition, since local problems become independent problems the parallel computing can be introduced to increase calculation efficiency. This study analyzes the numerical error of the globallocal iterative analysis method and evaluates the number of iterations in which the solution satisfies the convergence criteria. And increasing computational efficiency from the parallel computing using HPC system is also analyzed.