Gamma imaging devices that can accurately localize the radioactive contamination could be effectively used during nuclear decommissioning or radioactive waste management. While several hand-held devices have been proposed, their low efficiency due to small sensors have severely limited their application. To overcome this limitation, a high-speed gamma imaging system is under development which comprises two quad-type detectors and a tungsten coded aperture mask. Each quad-type detector consists of four rectangular NaI(Tl) crystals with dimensions of 146×146 mm2 and 72 square-type photomultiplier tubes (PMTs). The detectors are placed in front and back to serve as scatter and absorber, respectively, for Compton imaging. In addition, a coded aperture mask was fabricated in rank 19 modified uniformly redundant array pattern and placed in front of the scatter for coded aperture imaging. The system offers several advanced features including 1) high efficiency achieved by employing large-area NaI(Tl) crystals and 2) broad energy range of imaging by employing a hybrid imaging combining Compton and coded aperture imaging. The imaging performance of the system was evaluated through experiments in various conditions with different gamma energies and source positions. The imaging system provides clear images of the source locations for gamma energies ranging from as low as 59.5 keV (241Am) to as high as 1,330 keV (60Co). The imaging resolution was within the range of 7.5–9.4°, depending on gamma energies, when a hybrid maximum likelihood estimation maximization (MLEM) algorithm was used. The developed system showed high sensitivity, as the 137Cs source at distance, incurring dose rate lower than background level (0.03 μSv/h above background dose rate), could be imaged in approximately 2 seconds. Even under lower dose rate condition (i.e., 0.003 μSv/h above background dose rate), the system was able to image the source within 30 seconds. The system developed in the present study broadens the applicable conditions of the gamma ray imaging in terms of gamma ray energy, dose rate, and imaging speed. The performance demonstrated here suggests a new perspective on radiation imaging in the nuclear decontamination and radioactive waste management field.