The development of biochemical pesticides to replace existing chemical pesticides and the search for new substances with potential insecticidal ability are continuously required. The purpose of this study is to control myzus persicae with pyrethrum biochemical pesticide containing of high concentration of pyrethrin as an active ingredient. Pyrethrum dried powder was extracted with 95% ethanol for different periods of time and it was confirmed that the pyrethrin content increased as the extraction period increased and the extraction conditions for 20 days had the highest yield with 0.2% pyrethrin. We produced a prototype containing 0.13% pyrethrin content (pyrethrin II: 0.06%, pyrethrin I: 0.06%). and in 200 fold dilute spray condition. It showed a 77.2% corrected mortality against myzus persicae which is comparable to chemical pesticide. We are continuously researching to reduce the decomposition of active ingredients and look for additives to increase the insecticidal activity.