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Effect of weakly acidic hypochlorous acid water on the treatment of murine dermatitis infected with Microsporum canis KCI 등재
- 언어KOR
- URLhttps://db.koreascholar.com/Article/Detail/432465
pp.165-170
This study evaluated the fungicidal efficacy of weakly acidic hypochlorous acid water (WAHW) against Microsporum canis (M. canis) and its therapeutic effect on M. canis-infected mouse skin. WAHW was produced by a WAHW generation module. A fungicidal efficacy test by the broth dilution method was used to determine the lowest effective concentration of the WAHW. The lowest effective concentration of WAHW was less than 10 ppm. For T-1, T-2, and T-3, 30 ppm of WAHW was applied to the infected skin once, twice, and three times a day, respectively, and for T-4, 50 ppm of WAHW was applied once a day. On the 3rd day after the initiation of treatment, skin scores in all of the WAHW-treated groups were significantly decreased compared to those in the positive control group (PC) (p<0.05), and there were no significant differences compared to the normal control (NC). The area of the infected skin in all of the WAHW-treated groups was significantly decreased compared to PC from the first day after the initiation of WAHW treatment (p<0.05). The results showed that WAHW had a fungicidal efficacy on M. canis at less than 10 ppm, and it was effective in improving skin symptoms when 30 ppm of WAHW was applied to the M. canis-infected area once a day for five days or 50 ppm of WAHW was applied once a day.
재료 및 방법
공시균주 및 배양
WAHW의 생성
M. canis에 대한 소독효력시험
실험동물
시험군 구성 및 M. canis 피부 감염
WAHW 처리
육안적 관찰 및 평가
감염부위의 넓이 측정
통계학적 분석
결 과
M. canis에 대한 WAHW의 소독효력
피부반응
감염부위의 넓이 측정
고 찰
REFERENCES
