Tube, an intracellular protein of the Toll-pathway, forms a complex with Pelle and MyD88, and regulates a signal transduction to activate NF-κB in Drosophila. To understand the antimicrobial function of TmTube, the induction patterns of TmTube were investigated at 3, 6, 9, 12, and 24 h-post injection of pathogens into 10th to 12th instar larvae. In addition, we investigated the effects of TmTube RNAi on larval mortality and tissue specific AMP expression in response to microbial challenge. Our results will provide a basic information to elucidate the immunological function of TmTube

• Dong Woo Kang(Department of Biology, College of Natural Sciences, Soonchunhyang University)
• Ho Am Jang(Department of Biology, College of Natural Sciences, Soonchunhyang University, Korea Native Animal Resources Utilization Convergence Research Institute (KNAR), Soonchunhyang University)
• Seo Jin Lee(Department of Biology, College of Natural Sciences, Soonchunhyang University, Korea Native Animal Resources Utilization Convergence Research Institute (KNAR), Soonchunhyang University)
• Sung Min Ku(Department of Biology, College of Natural Sciences, Soonchunhyang University, Korea Native Animal Resources Utilization Convergence Research Institute (KNAR), Soonchunhyang University)
• Jea Hui Kim(Department of Biology, College of Natural Sciences, Soonchunhyang University, Korea Native Animal Resources Utilization Convergence Research Institute (KNAR), Soonchunhyang University)
• So Yeon Choi(Department of Biology, College of Natural Sciences, Soonchunhyang University)
• Yong Seok Lee(Department of Biology, College of Natural Sciences, Soonchunhyang University, Korea Native Animal Resources Utilization Convergence Research Institute (KNAR), Soonchunhyang University)
• Yeon Soo Han(Department of Applied Biology, College of Agriculture and Life Sciences, Chonnam National University)
• Yong Hun Jo(Department of Biology, College of Natural Sciences, Soonchunhyang University)