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Effects of TmPellino silencing on larval mortality and AMPs production

  • 언어ENG
  • URLhttps://db.koreascholar.com/Article/Detail/433501
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한국응용곤충학회 (Korean Society Of Applied Entomology)
초록

Pellino, a highly conserved E3 ubiquitin ligase, is known to mediate ubiquitination of phosphorylated Interleukin-1 receptor-related kinase (IRAK) homologs in Toll signaling pathway. To understand the immunological function of TmPellino, we screened the knockdown efficiency of TmPellino by injecting TmPellino-specific dsRNA into T. molitor larvae. Subsequently, we investigated the larval mortality and the tissue-specific expression patterns of antimicrobial peptide (AMP) genes against microbial challenges. Interestingly, the results indicate that the expression of many AMP genes was upregulated in the Malpighian tubules of TmPellino-silenced T. molitor larvae. This study may provide basic information to understand how Tmpellino regulates AMPs production in T. molitor.

저자
  • Jae Hui Kim(Department of Biology, College of Natural Sciences, Soonchunhyang University, Korea Native Animal Resources Utilization Convergence Research Institute (KNAR), Soonchunhyang University)
  • Ho Am Jang(Department of Biology, College of Natural Sciences, Soonchunhyang University, Korea Native Animal Resources Utilization Convergence Research Institute (KNAR), Soonchunhyang University)
  • Seo Jin Lee(Department of Biology, College of Natural Sciences, Soonchunhyang University, Korea Native Animal Resources Utilization Convergence Research Institute (KNAR), Soonchunhyang University)
  • Sung Min Ku(Department of Biology, College of Natural Sciences, Soonchunhyang University, Korea Native Animal Resources Utilization Convergence Research Institute (KNAR), Soonchunhyang University)
  • Dong Woo Kang(Department of Biology, College of Natural Sciences, Soonchunhyang University)
  • So Yeon Choi(Department of Biology, College of Natural Sciences, Soonchunhyang University)
  • Yong Seok Lee(Department of Biology, College of Natural Sciences, Soonchunhyang University, Korea Native Animal Resources Utilization Convergence Research Institute (KNAR), Soonchunhyang University)
  • Yeon Soo Han(Department of Applied Biology, College of Agriculture and Life Sciences, Chonnam National University)
  • Yong Hun Jo(Department of Biology, College of Natural Sciences, Soonchunhyang University)