Helicobacter pylori are known as a causative agent of gastritis, gastric duodenum and peptic ulcer, and gastric cancer, and multiple drug use is associated with various side effects in patients. The discovery of antibacterial substances against H. pylori from Korean resource plants is an important substitute for antibiotics. 52 species of Korean resource plants were collected and extracted with 50% ethanol, and antibacterial activity against H. pylori was measured using the disk diffusion method. The toxicity of plant extracts to human gastric adenocarcinoma(AGS) cells was measured by MTT assay, and the level of IL-8 secreted when gastric epithelial cells were inoculated with H. pylori was measured. As a result of measuring the antibacterial activity of H. pylori, antibacterial activity was confirmed in 38 plant extracts. The plant species with the strongest antibacterial activity were Chrysanthemum indicum, Rheum rhabarbarum, Patrinia scabiosaefolia and Petasites japonicus. C. indicum was not cytotoxic to H. pyroli-infected AGS cells and showed anti-inflammatory effects. This study's results can be used to develop healthy, functional foods and medical materials.

Introduction
Materials and Methods
    1. Sample collection
    2. Plant extract preparation
    3. Cell culture of H. pylori
    4. Determination of antibacterial activity of plant extractsagainst H. pylori
    5. Cytotoxicity measurement through MTT assay
    6. Measurement of IL-8 production inhibitory effectof plant extracts on gastric epithelial cells
    7. Statistical analysis
Results and Discussion
    1. Antibacterial activity of Korean resource plant extracts
    2. Cytotoxicity of plant extracts against H. pylori-infectedAGS cells
    3. Inhibition of IL-8 secretion by plant extracts ingastric epithelial cells infected with H. pylori
Acknowledgment
References

• Seong Hyeon Yong(Graduate student, Divisition of Environmental Forest Science, College of Agriculture & Life Science, Gyeongsang National University, Jinju 52828, Korea)
• Do Hyeon Kim(Graduate student, Divisition of Environmental Forest Science, College of Agriculture & Life Science, Gyeongsang National University, Jinju 52828, Korea)
• Kwan Been Park(Graduate student, Divisition of Environmental Forest Science, College of Agriculture & Life Science, Gyeongsang National University, Jinju 52828, Korea)
• Seung A Cha(Graduate student, Divisition of Environmental Forest Science, College of Agriculture & Life Science, Gyeongsang National University, Jinju 52828, Korea)
• Ji Hyun Lee(Graduate student, Divisition of Environmental Forest Science, College of Agriculture & Life Science, Gyeongsang National University, Jinju 52828, Korea)
• Seon A Kim(Graduate student, Divisition of Environmental Forest Science, College of Agriculture & Life Science, Gyeongsang National University, Jinju 52828, Korea)
• Jae Kyung Yang(Professor, Department of Environmental Material Science & Life Science, College of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Korea)
• Seung Chul Baik(Professor, Dept. of Medicine, Microbiology Major, College of Medicine, Gyeongsang National University, Jinju, 660-701, Korea)
• Myung Suk Choi(Professor, Divisition of Environmental Forest Science, College of Agriculture & Life Science, Gyeongsang National University, Jinju 52828, Korea) Corresponding author