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향나무 추출물의 Galectin-3 저해에 의한 암 전이 억제 효과 KCI 등재

Anti-Metastatic Activity of Juniperus chinensis Extract by Galectin-3 Inhibition

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  • URLhttps://db.koreascholar.com/Article/Detail/43514
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한국식품영양학회지 (The Korean Journal of Food And Nutrition)
한국식품영양학회 (The Korean Society of Food and Nutrition)
초록

The purpose of this study was to examine the anti-metastatic effect of Juniperus chinensis extract by inhibition of galectin-3 expression. For this study, we carried out the experiment of galectin-3 expression assay and in vivo metastasis mouse model bearing colon 26-M3.1 lung carcinoma, and also MMP-1, MMP-2 and MMP-9 inhibitory assays relating metastasis mechanism. J. chinensis extract significantly showed the inhibitory effect of basal expression and MNNG-induced expression of galectin-3 in colon 26-M3.1 lung carcinoma at the all tested doses (5, 50 and 500 ㎍/㎖). In case of the inhibition of MMP-1, MMP-2 and MMP-9, the weak activity was showed at the doses of 50 and 500 ㎍/㎖ and was not detected at the dose of 5 ㎍/㎖. However, J. chinensis extract significantly showed the anti metastatic activity on mouse mode bearing colon 26-M3.1 lung carcinoma. Therefore, this study strongly suggests that J. chinensis is a potent inhibitor of galectin-3 expression, and holds great promise for use in inhibiting metastasis induced by elevated expression of galectin-3.

저자
  • 이경호 | Ki-Hyeong Rhee
  • 이기형 | Keyong Ho Lee