This study focused on improving the solubility of silodosin, a drug poorly soluble in water, by utilizing solid dispersions. Three types of dispersions were examined and compared against the drug powder: surface-attached (SA), solvent-wetted (SW), and solvent-evaporated (SE). Polyvinyl alcohol (PVA) was identified as the most effective polymer in enhancing solubility. These dispersions were prepared using spray-drying techniques with silodosin and PVA as the polymer, employing solvents such as water, ethanol, and a water-acetone mix. The physicochemical properties and solubility of the dispersions were evaluated. The surface-attached dispersions featured the polymer on a crystalline drug surface, the solvent-wetted dispersions had the amorphous drug on the polymer, and the solvent-evaporated dispersions produced nearly round particles with both components amorphous. Testing revealed that the order of improved solubility was: solvent-evaporated, solvent-wetted, and surface-attached. The results demonstrated that the preparation method of the solid dispersions significantly impacted their physicochemical properties and solubility enhancement.

1. Introduction
2. Experimental
    2.1. 시약 및 기기
    2.2. 실로도신을 함유한 세 가지 고체분산체 제조
    2.3. 실로도신을 함유한 세 가지 고체분산체의 물리화학적 특성 분석
3. Results and Discussion
    3.1. 부형제 선정 및 고체분산체의 제조
    3.2. 실로도신 고체분산체의 물리화학적 특성 평가
4. Conclusion
Conflict of Interest Declaration
Author Information
Acknowledgement
References

• 이수만(경상국립대학교 제약공학과) | Su Man Lee (Department of Pharmaceutical Engineering, Gyeongsang National University, 33 Dongjin-ro, Jinju 52725, Republic of Korea)
• 송다영(경상국립대학교 제약공학과) | Da Young Song (Department of Pharmaceutical Engineering, Gyeongsang National University, 33 Dongjin-ro, Jinju 52725, Republic of Korea)
• 김경수(경상국립대학교 제약공학과) | Kyeong Soo Kim (Department of Pharmaceutical Engineering, Gyeongsang National University, 33 Dongjin-ro, Jinju 52725, Republic of Korea) Corresponding author